A virulent new disease is killing the children of Manhattan and has reached epidemic proportions. Peter Mann in desperation asks the entomologist, Dr. Susan Tyler, if she can help by killing the disease carrier, the common cockroach. Susan genetically engineers a new species of predatory insect to exterminate the cockroach and then die off. This novel solution works and the children recover but nature isn’t the laboratory and things don’t exactly go according to plan. Three years later people start to disappear, mutilated bodies are found and wild rumors of giant insects mimicking man start to emerge from the bag people living in the subway under Manhattan. Peter and Susan are called in to investigate. –IMDb
Guillermo Del Toro was born October 9, 1964 in Guadalajara Jalisco, Mexico. Raised by his Catholic grandmother, Del Toro developed an interest in filmmaking in his early teens. Later, he learned about makeup and effects from the legendary Dick Smith (The Exorcist, 1973) and worked on making his own short films. At the age of 21, Del Toro executive produced his first feature, Dona Herlinda and Her Son (1986). Del Toro got his first big break when Cronos (1993) won nine academy awards in Mexico, then went on to win the International Critics Week prize at Cannes. Following this success, Del Toro made his first Hollywood film, Mimic (1997), starring Mira Sorvino. Next for Del Toro, was El Espinazo del diablo (2001), a Spanish Civil War ghost story. The film was hailed by critics and audiences alike, and Del Toro decided to give Hollywood another try. In 2002, he directed the Wesley Snipes vampire sequel, Blade II (2002). —World Cinema Foundation
At his 2011 TIFF talk, Del Toro described this first brush with American studios as a demoralizing experience that very nearly killed his drive to make films; it also coincided with the kidnapping of his father. While those things have impacted the film, there are still some uniquely creepy Del Toro touches, even if you're not entomophobic. He gleefully broke two taboos in one scene: killing off children and a dog.