Emily and Martin, a successful New York couple, have their world turned upside down when a new drug intended to treat Emily’s anxiety, prescribed by her psychiatrist, has unexpected side effects.

During a prolific early 00s stretch—which brought us films as various as Haywire and Magic Mike—Soderbergh enlisted stars Rooney Mara and Channing Tatum for the audacious Side Effects. A pulp take on the pharmaceutical industry, a thriller Hitchcockian in form and absolutely of its zeitgeist.