This is probably the zenith of both Jared Hess and Mike White's brand of awkward Midwestern comedy (even though White didn't write it). The humor too often falls into the realm of sophomoric gross-out gags, with barf and feces serving as a frequent punchline, but I enjoyed myself. The performances are uniformly excellent and the story touches on some painful but recognizable truths for all writers out there.
The "reality" scenes were too much like Napoleon Dynamite (especially the character Dusty) yet not nearly as well executed. I think Hess was trying too hard to achieve the same success he had with ND but it ended up being way over done. That said, the Yeast Wars Scenes were EPIC! Sam Rockwell is the man. Also really liked how the Sci-fi book covers were used in the intro credits.
A film that tackles how the toxic self-interest of others can attempt to exploit and destroy artistic pursuits, Michael Angarano is like Harlan Ellison if he were meek and had grown up surrounded by tacky taste in Utah. The scene where he confronts his nemesis while wearing a woman's nighty is a brilliant image, but the delightful earnest innocence of Jared Hess's previous two films doesn't quite work for this tale.