Fu Manchu has seized a castle in Istanbul and there holds hostage the only scientist who knows of the chemical that can transform the oceans to ice and the only doctor who will perform the heart surgery needed to keep the scientist alive.
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Franco took his crew and cast on a vacation trip to Istanbul and filmed some barely comprehensive scenes with them. It was so terrible it wasn't released in several years and killed the franchise totally. Stock footage from better films and a laughable heart transplantation scene needs to be seen (and then unseen) in order to understand how stupid it is.