The Hitchhiker's Guide to the Galaxy in its section of statistics relating to the geo-social nature of the Universe says the following about Art: "[There is] none. Because the function of art is to hold a mirror up to nature, and there simply isn't a mirror big enough." Wiseau's, and now Franco's interpretation of him, most endearing quality is that he wouldn't give up on trying to hold up that mirror.
It's always hard for me to laugh at other people's expense. It's cruel. But James Franco manages to never cross the line as he treats his character with real empathy and tenderness. Out of this world, poignant and totally hilarious, even more when one is familiar with the original film.