Health-conscious Adam is devastated by the discovery of malignant tumors along his spine. With a 50/50 chance of survival he strives to stay positive. However, reactions from his mother and friend Kyle add to his challenges. Seeing a therapist the boundary between doctor and patient becomes blurred.

Based on writer Will Reiser’s own cancer experience, for which co-lead Seth Rogen also served as supportive friend, 50/50 pulls off a tricky balancing act between bawdy humor and pathos. Beautifully-judged performances enrich this look at how illness can complicate every relationship in your life.